When it comes to pain relief, ibuprofen and naproxen are two commonly used non-prescription medications. Both belong to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs), but they have differences that may influence your choice depending on your needs. In this article, we’ll compare ibuprofen and naproxen, looking at their effectiveness, side effects, dosing schedules, and more.
What Are Ibuprofen and Naproxen?
Ibuprofen and naproxen both work by reducing inflammation, pain, and fever. They inhibit the production of prostaglandins, chemicals in the body that promote inflammation. However, they differ in several key areas that may make one more suitable than the other for specific situations.
Key Differences Between Ibuprofen and Naproxen
Feature | Ibuprofen | Naproxen |
---|---|---|
Brand Names | Advil, Motrin, Nurofen, and others | Aleve, Naprosyn, and others |
Common Uses | Headaches, toothaches, menstrual cramps, arthritis, minor injuries | Arthritis, muscle pain, tendonitis, menstrual cramps |
Duration of Action | Shorter (4–6 hours) | Longer (8–12 hours) |
Dosing Frequency | Every 4–6 hours | Every 8–12 hours |
Side Effects | Nausea, dizziness, stomach upset, risk of ulcers | Stomach issues, kidney problems, risk of heart attack with long-term use |
Effectiveness | Good for mild to moderate pain | Effective for moderate to severe pain |
Over-the-counter Availability | Yes | Yes |
Which One Is Right for You?
Ibuprofen: Short-Term Pain Relief
Ibuprofen is often preferred for short-term pain relief, especially for conditions like headaches, toothaches, or minor injuries. It has a shorter duration of action, so it’s suitable for people who need quick, temporary pain management. However, frequent dosing may be required if the pain persists.

Naproxen: Longer-Lasting Relief
Naproxen, on the other hand, lasts longer in the body. It’s typically taken twice a day and is ideal for managing chronic conditions such as arthritis or muscle pain.
Because it stays in the system longer, naproxen can offer more continuous pain relief and is often preferred for conditions that require sustained management.
Side Effects to Consider
Both ibuprofen and naproxen share some similar side effects, such as gastrointestinal discomfort, dizziness, or headaches. However, naproxen may carry a higher risk of cardiovascular issues when used long-term.
Both medications can also cause stomach ulcers or gastrointestinal bleeding, particularly if taken without food or in large quantities.
Both ibuprofen and naproxen are effective NSAIDs, but they serve different purposes. Ibuprofen is better for short-term relief and conditions that require more frequent dosing, while naproxen is ideal for longer-lasting pain management.
It’s important to consider the nature of your pain, how long you expect to need pain relief, and your own health conditions before deciding which one to use.